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It plays a crucial role in protecting cells against oxidative stress by neutralizing reactive oxygen species such as free radicals and peroxides
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Biochemically, ferroptosis is indicated by the inhibition of cystine/glutamate antiporter (System Xc − ), the depletion of glutathione (GSH), decreased activity of glutathione peroxidase 4 (GPX4), accumulation of lipid peroxides (LOOH), and a decline in mitochondrial membrane potential (Mao et al., 2021
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