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It has also been shown that LPS (50 µg/kg, i.p.)-induced peripheral inflammation exacerbated ischaemic hippocampal cell loss after global brain ischaemia, independently of hippocampal pro-inflammatory cytokine production, hippocampal microglial activation or temperature changes (Spencer et al., 2007[66])

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5.2.3 Fecal microbiota transplantation FMT from healthy donors has been shown to restore microbial diversity in various conditions (Shimizu et al., 2025)