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Mechanistically, this compound can inhibit the NF-κB pathway and NLRP3 inflammasome activation, reducing inflammatory responses, restoring gut barrier function by enhancing goblet cells and tight junction proteins (ZO-1 and occludin) and modulating intestinal microbiota diversity [566]
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In diabetic pathology, DCs display metabolically programmed functional decay: Impaired efferocytosis in wound-resident DCs correlates with lysosomal acidification defects and dysregulated LC3-II expression (Masch et al., 2022)
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