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While many of these treatments induced both GCLC and GCLM expression, selective transcriptional induction of only GCLC occurred when cultured rat hepatocytes were treated with insulin or hydrocortisone [64–66]

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Efferent arm A little more than a decade ago, an important role of efferent vagus nerve cholinergic signalling in brain-to-immune communication was revealed by observations that vagus nerve stimulation suppresses local and serum proinflammatory cytokine levels in rodents with endo-toxaemia, and that acetylcholine inhibits the release of TNF, IL-1β and IL-18 from lipopolysaccharide-stimulated macrophages