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N G -nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and the NO-precursor L-arginine (200 mg/kg i.v.) (D-arginine was ineffective)

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This subclinical insufficiency — not enough for optimal neurotransmitter and homocysteine metabolism, but not low enough to produce obvious clinical signs — may be one contributor to the high rates of depression and elevated homocysteine in older American adults