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This study was supported by the Key Scientific and Technological Achievements Transformation Project of Ningxia Hui Autonomous Region (2024CJE09046) and the 2025 Research Project on Clinical Use Management of Medical Devices (2025TKA007)
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We're seeing elevated zonulin levels in: Celiac disease : Where gliadin directly triggers zonulin release Type 1 diabetes : Patients with T1D exhibit higher levels of serum zonulin, primarily in the early stages of the disease Inflammatory bowel diseases : Including Crohn's disease and ulcerative colitis Rheumatoid arthritis : Where intestinal permeability often precedes joint symptoms What's fascinating is that this suggests many autoimmune conditions may actually begin in the gut, with zonulin-mediated intestinal permeability serving as the initial trigger that allows the immune system to encounter antigens it was never meant to see
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