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using the Broad Institute’s Connectivity Map (cMap), a compendium of transcriptional responses to compounds, identified GHK as the most active of 1309 bioactive substances, uniquely capable of reversing the expression of 54 genes in a metastatic-prone signature for aggressive early stage mismatch-repair colorectal cancer

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Where possible, future studies should endeavor to rule out off-target metabolic effects, either by confirming minimal changes in the synthesis of metabolic off-targets or demonstrating that linked nitrogen metabolism pathways are not required for observed effects