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The injection sequence should follow these steps: Insert the needle at a 90-degree angle with a swift, confident motion (a 45-degree angle may be appropriate if specifically advised by your healthcare professional) If using a skin fold, maintain it gently throughout the injection Press and hold the dose button until the dose counter shows "0" Continue holding the button and count to at least six before withdrawing the needle—this crucial pause allows the full dose to be delivered and prevents medication leakage Withdraw the needle straight out at the same angle it was inserted If using a skin fold, release it after withdrawing the needle Do not rub the injection site afterwards, as this can cause irritation and affect absorption A common mistake leading to bubble formation is withdrawing the needle too quickly after injection

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Stress biomarkers inindividuals with fibromyalgia syndrome: a systematic review withmeta-analysis