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One of the defining characteristics of 5-Amino-1MQ is its relationship with NNMT inhibition
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Treated mice showed enhanced treadmill running distance and running time relative to vehicle controls, alongside induction of an ERRα-dependent acute aerobic exercise gene program in skeletal muscle (including Ddit4 and Slc25a25 upregulation) — a transcriptional signature resembling what is observed after endurance exercise
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