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Conversely, rare non-functioning mutations in ALPL cause a genetic condition called hypophosphatasia, which, in addition to high levels of pyrophosphate, causes high levels of P5P.[ref] Peripheral Neuropathy and Vitamin B6: Goldilocks vitamin Vitamin B6 deficiency is one of the more common causes of peripheral neuropathy.[ref][ref] On the other hand, excess consumption of vitamin B6 supplements for longer periods (months to years) has been shown to cause neuropathy or movement disorders in a few individuals