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Opening of the mitochondrial permeability transition pore is facilitated by direct depletion of the mitochondrial GSH (mtGSH), even in the absence of high (non-physiological) ROS levels [83]
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In eukaryotes, the use of degrons has progressed beyond the laboratory and has engendered a new drug discovery field named Targeted Protein Degradation (TPD), based on induced proteasomal degradation of target proteins (Verma et al., 2020)
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