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Regarding the activation of autophagy, oxidative stress represents such a factor, suggested in a study conducted by Desideri et al
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Moreover, the role of charge-charge interactions is as important as 18.18% (8/44, Table 5 in supplementary file supps.pdf ) for semaglutide analogue A747 to GLP-1R ECD, compared with 4.76% (2/42, Table 4 in supplementary file supps.pdf ) for native semaglutide to GLP-1R ECD, in the stabilization of the semaglutide backbone in complex with GLP-1R ECD (PDB ID: 4ZGM [24])
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