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GSCs have a radio- and chemo-resistant phenotype responsible for the constant relapse (Liu et al., 2015), in part because of the high expression of anti-apoptotic proteins and drug efflux transporters (Nakai et al., 2009) and the constitutive activation of the DNA repair element, poly-ADP-ribose polymerase 1

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In CRC, for example, male patients exhibit distinct right-left colon differences in secondary BA accumulation and Treg cell infiltration that are not mirrored in females (75)